Lynx – A Friend with Benefits
Lynx employs a wide range of enabling technologies that deliver new levels of performance, robustness and data integrity to your automated liquid handling workflow.
VVP Technology
Award-winning Volume Verified Pipetting (VVP) technology represents the very latest in air-based 8, 24 & 96 multi-channel pipetting.
Highly sensitive in-line flow sensors integrated into each and every channel translates to unique pipetting competencies
Independent Volumes on All Channels
- Superior flexibility for 96 & 24-channel automated liquid handling
- Expands pipetting workflow efficiency by several-fold over traditional tools
- Perform plate normalizations, serial dilutions & other common routines in record time
Direct Volumetric Measurement of Each & Every Transfer
- Ultimate pipetting confidence with real-time volume verification
- Removes the guesswork from automated liquid handling once-and-for-all
- Any liquid, at any volume…with zero liquid class development
Live Pipetting Diagnostics & Error Recovery
- New levels of process security with continuous QC monitoring of all channels
- More robust workflows with advanced user-defined recovery for ‘on-the-fly’ corrections
- Final validation data report captures all pipetting data
How VVP Works
VVP air-based pipetting tools perform all aspirate and dispense functions via precise control of vacuum and positive pressure, respectively.
A silicon chip-based MEMS micro-sensor assembly incorporated into each liquid channel measures the pressure differential across a known constriction. Volumetric flow rate is a linear function of this pressure differential, allowing for instantaneous calculation of the actual volume of liquid entering or leaving each tip.
By monitoring and adjusting to volumetric flow in real-time, all pipetting processes can be controlled and finely tuned for any liquid, automatically accommodating for temperature and viscosity differences.
Liquid Level Detection (LLD) with VVP
Independent-channel LLD on all liquid types is performed via controlled micro-releases of air from the distal end of the tip and subsequent monitoring of pressure changes associated with meniscus (or bubble/foam) interference. A residual volume based on the confirmed meniscus height and labware definition is calculated. Any pipetting discrepancies experienced are addressed via several user-defined error recovery options.
Air-based VVP technology accomplishes robust LLD without the need for more expensive carbon-impregnated (capacitance-based LLD) disposable tips. For the best pipetting results, be sure to use D2-brand ‘performance-certified’ clear disposable tips.
Pipetting Diagnostics with VVP
VVP performs continuous millisecond analysis of flow rates for each liquid channel. A disruption in the expected average flow rate, produced either by air entering the channel (i.e. ‘short or no sample’) or a blockage (i.e. clot/clog) triggers an alert.
Diagnosed pipetting errors are addressed automatically ‘on-the-fly’ via user-defined error recovery options.
Independent control of each channel affords the freedom to isolate and disable only the offending channel(s), allowing the method to continue without interruption.
Upon method completion, a final Error Report file is generated.
Advanced Clot/Clog Detection & Correction
Characteristics of the sample matrix are used to set specific flow rate measurement thresholds, allowing optimal detection and recovery from blockages such as clots or clogs. Upon detection, affected channel(s) are disabled and remaining tips finish aspirating. Upon completion, the VVP head is raised, affected tip(s) cleared and an ‘intra-well re-aspiration’ is performed.
Short Sample/No Sample Detection & Correction
Flow rate changes caused by introduction of air into the sample column during aspiration are used to diagnose a ‘short sample’ or ‘no sample’ specimen. Recovery options include skip the sample, re-aspirate, sample blow-back, or dispense and report the actual volume transferred.
VVP Tools
Featuring next-gen integrated flow sensor technology. Fast and flexible, perfectly suited for liquid handling in single microliter to milliliter volumes.
96VVP Pipetting Tool
96 channel (8×12) head; fixed 9mm spacing
- 96 independent volumes with LLD & Pipetting Dx on each channel
- Wide dynamic range: 1.5 μL – 1,250 μL/channel
- 96 volume transfers simultaneously monitored, verified and recorded in real-time
The only 96-channel head on the market with 96 independent volumes, allowing for new levels of flexibility and efficiency. Yields unsurpassed speed in combinatorial pipetting routines, normalization, serial dilutions, pooling, hit picking and complex plate layouts.
24VVP Pipetting Tool
24 channel (4×6) head; fixed 18mm spacing
- 24 independent volumes with LLD & Pipetting Dx on each channel
- Wide Dynamic Range: 50 μL – 5,000 μL/channel*
- 24 verified volume transfers simultaneously monitored, verified and recorded in real-time
*using D2 performance-certified DDX-24 5mL disposable tips
The only 24-channel head on the market with 5mL/channel capacity. Ideal for applications such as liquid biopsy sample distribution and large volume DNA mag-bead based extraction. 24 independent volumes offers flexibility for more complex pipetting routines.
Fixed 8VVP Pipetting Tool
8 channel (1×8) tool; fixed 9mm spacing
- 8 independent volumes
- Wide Dynamic Range: 1.5 μL – 1,250 μL/channel
- 8 verified volume transfers simultaneously monitored, verified and recorded in real-time
The Lynx’s entry-level VVP tool (f8) transfers 8 independent volumes of liquid with verified volume reporting and full pipetting diagnostics. For samples within microplate format you can now validate your transfers with our fixed-8 tip VVP Pipetting Tool. By eliminating the independent spreading and Z axis capabilities, multiple axis control is reduced, providing a highly economical yet functional VVP pipetting tool.
f4iz Pipetting Tool
4 channel (1×4) tool; independent z-axis
- 4 independent volumes
- Wide Dynamic Range: 1.5 μL – 1,250 μL/channel
- Independent z-axis motion per individual tip
- Independent access to variable spaced tubes and individual wells possible
- Verified and recorded in real-time
With independent Z-axis control, gain individual access to variable spaced tubes and
wells, allowing for precise handling of samples with unmatched flexibility. Whether
you’re working with diverse sample matrices or conducting intricate assays, the F4iZ
VVP pipetting tool delivers unparalleled performance, empowering you to achieve your
research goals with confidence.
Standard Technology (ST) Pipetting Tools
Traditional syringe-drive air-based pipetting; uniform volume across all channels. An economical solution for many liquid-handling applications such as plate stamping. Single, row and column tip pick up. For 24, 96, 384 & 1536-well plate-based liquid handling routines.
24ST Pipetting Tool
24 uniform volume channels
Our 24 ST Pipetting Tool allows 24 5mL disposable tips to be used for uniform volume transfers. Fast pipetting of all your large volume samples. Now accomplish applications like In-Parallel Mag Bead Extraction.
96ST Pipetting Tool
96 uniform volume channels; 8×12 array; fixed 9mm spacing
Our 96 ST Pipetting Tool allows the transfer of wells, rows, columns or entire 96 well plates across 96, 384 or even 1536 well plates. In this ST syringe based design, identical volumes are transferred in every channel. The dual disposable tip mandrel design provides options for low and high volume configurations. With replaceable CORE insert pipetting blocks, the 96 ST syringe pipetting tool is the most economical for high throughput liquid handling.
384ST Pipetting Tool
384 uniform volume channels; 16×24 array; fixed 4.5mm spacing
With the high loading force required to load 384 simultaneous tips, the Lynx is specifically engineered to load these tips from any worktable position. No specific loading areas or specialty tip loading tools required. Simply place the 384 tip box(es) in any microplate position and run your method with the versatility you expect from your Lynx LM Series Workstation.
96-well plates – Pipetting range by tool/tip type*
*lower volumes may be achieved under optimal conditions
384-well plates – Pipetting range by tool/tip type*
*lower volumes may be achieved under optimal conditions
1536-well Plate Pipetting
Positional Accuracy and Reproducibility
Linear drive motors coupled with x/y axes positional encoders provides unparalleled accuracy and zero drift over time. < 0.1 mm positional resolution allows robust pipetting to high-density 1536-well plates.
Lynx Platform
Lynx incorporates a series of enabling technologies for robust performance and reduced maintenance.
Absolute positioning with Linear Magnetic Motors and Encoders
Linear motors and encoders offer enhanced positional accuracy, precision, and repeatability compared to traditional mechanical rota-tion-to-translation mechanisms like racks & pinions or belts & pulleys typically used in laboratory liquid handling instruments. Moreover, they contribute to higher speeds, decreased maintenance requirements, and improved performance in pipetting tools.
Low Maintenance Solid Mandrel Tip Loading
The Solid Mandrel (SM) tip adapters, designed for loading disposable pipette tips, have eliminated the necessity of maintaining high-maintenance components such as rubber O-rings and tip seals. By adopting SM tip loading, the requirement for a 3 or 6-month preventive maintenance service is avoided, as it excludes the most maintenance intensive component on the robot.
Flexibility with an Unrestricted Worktable
The Lynx worktable features SBS-compliant microplate footprints in each position, providing flexibility for organizing plates, tips, or disposables. With a robust chassis and vertical drive, the Lynx can load 96 or 384 tips from any of its 66 worktable locations. This versatility, along with a complete line of disposable tips in SBS free-standing tip boxes, creates a highly efficient and flexible worktable.
Open Design For Flexible Integration
The Lynx offers versatile integration possibilities ranging from basic pipette head grippers to 6-axis SCARA robots capable of reaching off the deck. Its open chassis design enables integration from all four sides, and it accommodates horizontal conveyor options and vertical incorporation through the work-table.
Lynx Platform Decks Sizes
Sizes & Capacities
Flexible, space-efficient decks to fit your ideal throughput and walk-away time; 5 models to choose from:
Dynamic Loading & Storage Integration
We’re excited to introduce to you the NEWEST member of the Dynamic Devices product line Qdex!
With the need for speed and ultimate flexibility, the NEW Qdex will solve your workflow bottlenecks holding up to 60 trays at a time.
As displayed at SLAS 2020, Qdex is available for continuous operation with dynamic loading giving you uncompromising performance.
Virtual Deck | Faster Access | Random Access | Batch Processing | Continuous Loading | Multi-User Availability | SBS & Custom Labware | 4x the capacity
No more waiting to load or unload plates or trays
Normalize 270 plates in less than 4 hours
Exchange a tray of 9 plates in 30 seconds
18 virtual deck positions available
Seamless Integration with Lynx Workstation
Dynamic Loading/Unloading of Trays
Holds up to 60 Trays at a Time
Gripping & Device Integration
Head Gripper Tool
cost-effective solution for on-deck labware transport; fingers configured onto 96 or 384 head arms; plate stacking/unstacking, lidding/de-lidding plates, move mag and vac separation devices, discard empty tip boxes and more
‘iPaw’ Internal Gripper Tool
flexible solution for on and off-deck labware transport; separate frame mounted arm ideal for hand-offs to readers, washers and other peripheral integrated devices; can ‘cross-over’ pipetting arms for increased flexibility and provide pipetting arms with increased access to on-deck positions
Scanning
1D & 2D Scanning
integrated barcode scanning modules capable of efficient scanning of 1D and 2D barcodes on tubes and plates; affords highly secure sample tracking and chain-of-custody reporting
Instrument Control Software
Simplified Instrument Control
With Method Manager 4.0 (MM4), controlling your Lynx is made easy. MM4 provides a practical approach to method programming, worklist importing, runtime control, pipetting data exporting and diagnostics reporting. And no matter the size of your Lynx, all use the same MM4 software for consistency across the entire Lynx platform.
Lynx Certified Disposable Tips
Clear Tips
Lynx uses high-quality CLEAR disposable tips for all pipetting and liquid level detection, eliminating the need for expensive black polycarbonate tips. VVP flow sensor technology allows for robust LLD in both tubes and plates and can accommodate compromised samples containing clots, bubbles or foam. Several sizes and filtered/unfiltered versions are available
Standard Boxes
All Lynx-brand tips are housed in ANSI-standard containers, allowing for placement anywhere on the deck. Tip pick-up directly from sturdy tip boxes eliminates the need for dedicated racks or tip loaders.