Automating cfDNA Extraction tor Aneuploidy Screening on the Dynamic Devices Lynx

Presenter: Sarabeth Schommer from Billion to One

The presentation will initially discuss BillionToOne as a company and current automated lab processes. The majority of the talk will focus on the development period, validation, assay performance, and future improvements of our cfDNA extraction process for Aneuploidy screening on the Lynx platform. The presentation will end discussing future improvement

Sarabeth Schommer is a Senior Automation Engineer working in the Prenatal division at BillionToOne. She received a B.S. in Biomedical Engineering from UC Davis and an M.S. in Biotechnology and Management from Mount St. Mary’s. She has worked with automation for 7 years as both a vendor and internal engineer developing and improving automated processes.

Automating Magnetic Bead Purifications of TubeSpin Bioreactors With the MagLynx

Presenter: Caleb Cassidy-Amstutz from Gilead

Caleb Cassidy-Amstutz is a Principal Scientist for Gilead Sciences where he leads the Automation team. Caleb began his automation career at BMS where he developed automated platforms to support early antibody discovery.  At Gilead, Caleb built a plate based high throughput production workflow and oversaw improvements to the mid-scale workflow including onboarding of a magnetic bead-based purification strategy.

Optimizing cfDNA Extractions on the Dynamic Devices Lynx

Presenter: Chris Lee from Omega Biotek

Automated Library Preparation of Arrayed Multi-Guide gRNA Libraries

Presenter: Grant Mishler from Edit Co

EditCo’s core mission is to provide access to reproducible and high-quality gene-editing solutions to empower researchers to push the boundaries of scientific discovery. Our Arrayed gRNA Libraries and Gene Knockout Kit products provide customers with highly-customizable libraries designed for targeted gene knockout using our multi-guide strategy to create predictable knockouts with high-efficiency and reduce false negatives.

The core of our guide fulfillment platform is an automated inventory system and fulfillment workcell. With approximately 20,000 different recognized protein-coding genes in the Whole Human Genome, differences in storage concentration, suspended volume, and lot uniqueness can greatly complicate the process of delivering material into destination labware. At EditCo Bio, we have resolved much of that complexity by choosing the Dynamic Devices Lynx LM system, especially the Volume Verified Pipetting (VVP) technology. In this presentation, we will discuss the dynamic requirements of our library fulfillment system and how the Lynx enables our platform to normalize transferred gRNA yields into destination labware for up to 2,000 samples per day.

Grant Mishler is a Sr. Automation & Systems Engineer at EditCo Bio. With a background originally in mechatronics and aerospace engineering, he is focused on creating multi-disciplinary solutions to the challenges of using automation to scale production systems to new levels.

Enhancing Operational Efficiency and Driving Innovation With the Dynamic Devices Lynx

Presenter: Robyn Laskowski from LGC Group

Robyn Laskowski is the Senior Manager of LGC Lab Services in Middleton, Wisconsin, with over a decade of experience in the Applied markets. She specializes in developing and implementing high-throughput genotyping technologies globally and has successfully navigated the challenges associated with them. In her current role, Robyn is focused on scaling LGC’s global service laboratories to deliver high-quality results that meet customer turnaround time and cost expectations. She is dedicated to continuously improving the customer experience while driving operational efficiency and innovation.

Solvent Liquid Handling: Lynx Method Basics

Presenter: Christopher George from Precision Analytical Inc

Christopher George is the Lab Systems and Automation Manager at Precision Analytical Inc., specializing in automation, systems integration, and workflow optimization in a CLIA-regulated environment. He oversees 8 Lynx liquid handlers, legacy systems, and 7,000 ft² of lab space, managing data processing systems and developing innovative solutions like a methanol recycling process. Outside of work, Christopher enjoys 3D printing, home servers, and IoT projects.

A Dynamic Devices Lynx Method to Dynamically Normalize and Prepare Oligonucleotide Pools from 384-Well Plates With Data 1/0 tor Automated LIMS Updating

Presenter: Derek Burr from Bruker

Derek Buhr is an Automation Engineer working for Bruker Spatial Biology (BSB) with 8 years of experience developing and implementing consumables automation for the CosMx and GeoMx spatial biology platforms. His work at BSB has encompassed extensive liquid-handling programming and development of a custom LIMS for inventory and workflow tracking of over 100K+ unique oligonucleotides. Today, Derek will be presenting how BSB has implemented the Dynamic Devices Lynx to dynamically normalize and create pools for R&D and commercial products using database produced inputs and Lynx based outputs.

Automation Decision Making and Workflow Application

Presenter: Kevin Kho from Alpine Bio/ Noble foods

Robotic Power: Boosting High-Throughput Phenotyping Efficiency

Presenter: Clay Overturf from Genomatica

Scalable Protein Expression and High Throughput Characterization through Mass Spectrometry
enabled by Lynx

Presenter: Benjamin Lee from BMS

With 96 individually addressable channels, the Lynx Liquid Handler delivers unmatched precision for high-throughput applications, allowing each sample to be processed independently, making it ideal for smaller-scale and more complex higher-throughput workflows to support screening workflows. At the same time, the Lynx seamlessly handles larger-volume workflows, easily handling up to 25mL workflows, offering versatility across applications. This flexibility makes it the perfect choice to support our high-throughput protein expression and complex mass spectrometry workflows, ensuring consistent and reliable results.

As a Senior Automation/Full-stack Software Engineer at Bristol Myers Squibb (BMS) in the SD Biotherapeutics division, Benjamin Lee spearheaded the automation of protein production workflows using Lynx, improving efficiency, reducing manual work, and speeding up timelines. To manage the growing volume of data from these workflows, Benjamin Lee developed a range of custom software solutions, including a high-throughput (HTP) mass spectrometry analysis tool. This tool streamlined the mass spec analysis process, cutting analysis time by over 80%, and enhancing both the speed and accuracy of data processing. By leveraging a combination of software and machine automation, Benjamin Lee played a key role in increasing throughput and automating complex workflows, driving significant improvements in research efficiency at BMS.